کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1968277 1538762 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The formation and rapid clearance of a truncated albumin species in a critically ill patient
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
The formation and rapid clearance of a truncated albumin species in a critically ill patient
چکیده انگلیسی

IntroductionHypoalbuminemia is known to occur in critically ill patients and is associated with increased mortality. We observed a potentially novel, partial explanation for the hypoalbuminemia noticed in a severely traumatized patient.Case reportWe report of a severely, multi-system traumatized patient in whom hypoalbuminemia was present (1–2 g/dl). The plasma albumin (HSA) was analyzed by liquid chromatography/positive electrospray ionization mass spectrometry. A high percentage of a truncated albumin that lost its carboxy terminal amino acid leucine (HSA-L) associated with a 10-fold increase in plasma carboxypeptidase A (CPA) activity (R2 = 0.994) were found. We estimated the half life of this truncated albumin species to be < 80 h.ConclusionsThe increased CPA activity encountered following a traumatic event and subsequent rapid clearance of the resulting HSA-L from plasma might be a contributing factor to the hypoalbuminemia observed in the critically ill patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 365, Issues 1–2, March 2006, Pages 346–349
نویسندگان
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