کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1980782 1061880 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
DNA repair gets physical: Mapping an XPA-binding site on ERCC1
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
DNA repair gets physical: Mapping an XPA-binding site on ERCC1
چکیده انگلیسی

Two recent reports provide new physical information on how the XPA protein recruits the ERCC1–XPF heterodimer to the site of damage during the process of mammalian nucleotide excision repair (NER). Using chemical shift perturbation NMR experiments, the contact sites between a central fragment of ERCC1 and an XPA fragment have been mapped. While both studies agree with regard to the XPA-binding site, they differ on whether the ERCC1–XPA complex can simultaneously bind DNA. These studies have important implications for both the molecular process and the design of potential inhibitors of NER.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: DNA Repair - Volume 7, Issue 5, 3 May 2008, Pages 819–826
نویسندگان
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