کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1980799 1061881 2009 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
DNA replication as a target of the DNA damage checkpoint
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
DNA replication as a target of the DNA damage checkpoint
چکیده انگلیسی

Faithful inheritance of the genome from mother to daughter cell requires that it is replicated accurately, in its entirety, exactly once. DNA replication not only has to have high fidelity, but also has to cope with exogenous and endogenous agents that damage DNA during the life cycle of a cell. The DNA damage checkpoint, which monitors and responds to defects in the genome, is critical for the completion of replication. The focus of this review is how DNA replication is regulated by the checkpoint response in the presence of DNA damage and fork stalling agents.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: DNA Repair - Volume 8, Issue 9, 2 September 2009, Pages 1077–1088
نویسندگان
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