کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1981614 | 1539419 | 2015 | 6 صفحه PDF | دانلود رایگان |
• We examine the role of EGCG, a major polyphenol in green tea, in bone metabolism.
• LPS is a pathogen-associated molecule, and induces inflammatory bone resorption.
• EGCG suppresses the LPS-induced PGE production in osteoblasts.
• EGCG suppresses the LPS-induced bone resorption of alveolar bones in vitro.
• In the mouse model of periodontitis, EGCG restores the loss of alveolar bone mass.
Epigallocatechin gallate (EGCG), a major polyphenol in green tea, possesses antioxidant properties and regulates various cell functions. Here, we examined the function of EGCG in inflammatory bone resorption. In calvarial organ cultures, lipopolysaccharide (LPS)-induced bone resorption was clearly suppressed by EGCG. In osteoblasts, EGCG suppressed the LPS-induced expression of COX-2 and mPGES-1 mRNAs, as well as prostaglandin E2 production, and also suppressed RANKL expression, which is essential for osteoclast differentiation. LPS-induced bone resorption of mandibular alveolar bones was attenuated by EGCG in vitro, and the loss of mouse alveolar bone mass was inhibited by the catechin in vivo.
Journal: FEBS Open Bio - Volume 5, 2015, Pages 522–527