کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1983967 1539913 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Small heat shock protein expression and functions during development
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Small heat shock protein expression and functions during development
چکیده انگلیسی

The expression of small heat shock proteins is tightly regulated during development in multiple organisms. As housekeeping proteins, small heat shock proteins help protect cells from apoptosis, stabilize the cytoskeleton and contribute to proteostasis. Consistently, depletion of one small heat shock protein is usually not detrimental due to a certain level of redundancy between the functions of each small heat shock protein. However, while their stress-induced expression is regulated by heat shock factors, their constitutive expression is under the control of other specific transcription factors, suggesting the existence of very specialized functions. This review focuses on the expression patterns and functions of small heat shock proteins in various organisms during development.This article is part of a Directed Issue entitled: Small HSPs in physiology and pathology.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 44, Issue 10, October 2012, Pages 1613–1621
نویسندگان
, ,