کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1988424 | 1540394 | 2008 | 4 صفحه PDF | دانلود رایگان |
Workers involved in the manufacture of drug substances may be exposed to active pharmaceuticals by inhalation of drug dusts or droplets which has been considered the main exposure route. The proposed HPLC method allowed to determine sulpiryde, hydroxyurea and dyprophylline in the concentration range of 0.01–0.187 mg/m3, 0.001–0.08 mg/m3 and 0.01–0.40 mg/m3 for sulpiryde, hydroxyurea and dyprophylline, respectively, when 480 L of air sample was collected on the glass fibre filters. Sulpiryde was extracted with a solvent system consisting of acetonitrile–phosphate buffer at pH 3 (85:15, v/v), while the best efficiency of extraction for hydroxyurea and dyprophylline was achieved using water. HPLC analysis of sulpiryde with fluorescence detection was more sensitive (LOD = 3.1 μg/L) in comparison with UV detection (LOD = 84.4 μg/L).
Journal: Journal of Biochemical and Biophysical Methods - Volume 70, Issue 6, 24 April 2008, Pages 1283–1286