کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1989529 1540634 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A diet containing grape powder ameliorates the cognitive decline in aged rats with a long-term high-fructose-high-fat dietary pattern
ترجمه فارسی عنوان
یک رژیم حاوی عصاره انگور موجب کاهش شناختی در موش های سالم می شود که دارای الگوی رژیم غذایی بلند مدت با قند فروکتوز با چربی بالا هستند
کلمات کلیدی
پلی فنل، آمیلوئید بتا، بتا-اسید اسید، نسل ناباروری، انگور، توابع شناختی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی

Research has suggested that the consumption of foods rich in polyphenols is beneficial to the cognitive functions of the elderly. We investigated the effects of grape consumption on spatial learning, memory performance and neurodegeneration-related protein expression in aged rats fed a high-fructose-high-fat (HFHF) diet. Six-week-old Wistar rats were fed an HFHF diet to 66 weeks of age to establish a model of an HFHF dietary pattern, before receiving intervention diets containing different amounts of grape powder for another 12 weeks in the second part of the experiment. Spatial learning, memory performance and cortical and hippocampal protein expression levels were assessed. After consuming the HFHF diet for a year, results showed that the rats fed a high grape powder-containing diet had significantly better spatial learning and memory performance, lower expression of β-amyloid and β-secretase and higher expression of α-secretase than the rats fed a low grape powder-containing diet. Therefore, long-term consumption of an HFHF diet caused a decline in cognitive functions and increased the risk factors for neurodegeneration, which could subsequently be ameliorated by the consumption of a polyphenol-rich diet.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Nutritional Biochemistry - Volume 34, August 2016, Pages 52–60
نویسندگان
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