کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1990184 | 1540675 | 2013 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hepatoprotective effect and mechanistic insights of deoxyelephantopin, a phyto-sesquiterpene lactone, against fulminant hepatitis
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کلمات کلیدی
DAPIPoly (adenosine diphosphate-ribose) polymeraseDeoxyelephantopinD-GalNZnPPFHFSOCS3TIMP-1Heme oxygenase-1PARPSTAT3ALTiNOSMMP-9COX-2HO-1DETLPSIL-6NF-κBJnk3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide - 3- (4،5-dimethylthiazol-2-yl) -2،5-difenyl tetrazolium bromide4,6-diamidino-2-phenylindole - 4،6-دیامیدین-2-فنیلینولc-Jun N-terminal kinase - C-Jun N-terminal kinased-Galactosamine - d-گالاکتوزامینMTT - MTTHepatobiliary scintigraphy - scintigraphy hepatobiliaryAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Alanine aminotransferase - آلانین آمینوترانسفرازinterleukin-6 - اینترلوکین ۶SPECT - برشنگاری رایانهای تک فوتونی، مقطع نگاری رایانهای تک فوتونی، توموگرافی رایانهای تک فوتونی، اسپکتtumor necrosis factor-alpha - تومور نکروز عامل آلفاsingle-photon emission computed tomography - توموگرافی کامپیوتری انتشار یک تک فوتونHepatoprotection - حفاظت از هپاتیتsuppressor of cytokine signaling-3 - سرکوبگر سیگنالینگ سیتوکین-3inducible nitric oxide synthase - سنتاز اکسید نیتریک القاییCyclooxygenase-2 - سیکلوکوکسیژناز2Fulminant hepatic failure - شکستگی کبدی کاملTNF-α - فاکتور نکروز توموری آلفاnuclear factor-kappaB - فاکتور هسته ای - kappaBElephantopus scaber - فیله سیاهlipopolysaccharide - لیپوپلی ساکاریدMatrix metalloproteinase-9 - ماتریکس متالوپروتئیناز -9signal transducer and activator of transcription 3 - مبدل سیگنال و فعال کننده رونویسی 3Tissue inhibitor of metalloproteinase 1 - مهار کننده بافت متالوپروتئیناز 1zinc protoporphyrin IX - پروپوپورفیرین IX روی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Hepatoprotective effect and mechanistic insights of deoxyelephantopin, a phyto-sesquiterpene lactone, against fulminant hepatitis Hepatoprotective effect and mechanistic insights of deoxyelephantopin, a phyto-sesquiterpene lactone, against fulminant hepatitis](/preview/png/1990184.png)
چکیده انگلیسی
Deoxyelephantopin (DET) is an abundant sesquiterpene lactone isolated from an anecdotally hepatoprotective phytomedicine, Elephantopus scaber. Our objective in this study was to provide scientific evidence for the in vivo efficacy and the underlying mechanisms of action of DET in lipopolysaccharide/d-galactosamine (LPS/D-GalN)-induced fulminant hepatitis. We investigated both the protective effect of pretreatment with DET (10 mg/kg body weight, Pre-DET10) prior to administration of LPS/D-GalN and the therapeutic effect of treatment with 10 mg/kg DET (Post-DET10) or the hepatoprotective drug silymarin (Post-SM10) following the administration of LPS/D-GalN. Our data showed that Pre-DET10 prevented LPS/D-GalN-induced infiltration of F4/80 monocytes/macrophages and an increase of nitrotyrosine and cyclooxygenase-2 protein in liver tissues. Further, Post-DET10 and Psot-SM10 treatments protected against liver cell apoptosis. All three treatments suppressed serum aminotransferase activities, tumor necrosis factor-alpha and interleukin-6 levels, and serum and hepatic matrix metalloproteinase-9 activity. The Pre-DET10 or Post-DET10 and Post-SM10 treatments in combination with inhibition of heme oxygenase-1 expression ultimately decreased protection of mice from LPS/D-GalN-induced mortality, with decreased survival from 75% and 62.5% to 50%, respectively. Results obtained from serial liver scintigraphy with 99mTc-diisopropyl iminodiacetic acid (DISIDA) on single-photon emission computed tomography analysis showed that both liver uptake and excretion times of DISIDA were significantly delayed in LPS/D-GalN-treated animals and were effectively recovered by DET and silymarin treatment. This report demonstrates that DET functions in the modulating multiple molecular targets or signaling pathways that counteract inflammation during the progression of fulminant hepatitis and may serve as a novel lead compound for future development of anti-inflammatory or hepatoprotective agents.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Nutritional Biochemistry - Volume 24, Issue 3, March 2013, Pages 516-530
Journal: The Journal of Nutritional Biochemistry - Volume 24, Issue 3, March 2013, Pages 516-530
نویسندگان
Chi-Chang Huang, Kun-Ju Lin, Ya-Wen Cheng, Chih-An Hsu, Sien-Sing Yang, Lie-Fen Shyur,