Estrogen receptor β signaling regulates the progression of Chinese non-small cell lung cancer

► Over expressed ERβ can promote the development of Chinese NSCLC. ► Down-regulation of ERβ gene can inhibit growth of Chinese NSCLC cells and induce their apoptosis. ► ERβ specific siRNA can induce NSCLC apoptosis via mitochondrial depolarization and caspase-3 activation.