کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1994696 | 1541284 | 2015 | 8 صفحه PDF | دانلود رایگان |
• An effective, nonlinear, lumped-parameter model for blood flows in capillary beds.
• Physiologically meaningful model derived from first-principles of fluid mechanics
• Explicit expressions for previously empirical resistance–compliance curves
• Model provides accurate functional form for hypo-, normo- and hyper-tensive phenomena.
• Validation against accepted experimental data sets in the literature
In this article we derive applicable expressions for the macroscopic compliance and resistance of microvascular networks. This work yields a lumped-parameter model to describe the hemodynamics of capillary beds. Our derivation takes into account the multiscale nature of capillary networks, the influence of blood volume and pressure on the effective resistance and compliance, as well as, the nonlinear interdependence between these two properties. As a result, we obtain a simple and useful model to study hypotensive and hypertensive phenomena. We include two implementations of our theory: (i) pulmonary hypertension where the flow resistance is predicted as a function of pulmonary vascular tone. We derive from first-principles the inverse proportional relation between resistance and compliance of the pulmonary tree, which explains why the RC factor remains nearly constant across a population with increasing severity of pulmonary hypertension. (ii) The critical closing pressure in pulmonary hypotension where the flow rate dramatically decreases due to the partial collapse of the capillary bed. In both cases, the results from our proposed model compare accurately with experimental data.
Journal: Microvascular Research - Volume 100, July 2015, Pages 40–47