کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1995195 | 1064956 | 2008 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The “mode” of lymphocyte extravasation through HEV of Peyer's patches and its role in normal homing and inflammation
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کلمات کلیدی
HEVICAM-1mucosal vascular addressin cell adhesion molecule 1SLCMAdCAM-1GTPaseLFA-1ExtravasationVCAM-1CCL21Lymphocyte function-associated antigen-1 - آنتی ژن 1 مرتبط با عملکرد لنفوسیتinflammation - التهاب( توروم) Homing - تعطیلاتLymphocyte - لنفوسیتtransendothelial migration - مهاجرت transendothelialintercellular adhesion molecule-1 - مولکول چسبندگی بین سلولی -1vascular cell adhesion molecule-1 - مولکول چسبندگی سلولی عروقی-1high endothelial venule - ونول اندوتلیوم بالاsecondary lymphoid tissue chemokine - کومکوین بافت لنفوئیدی ثانویهguanosine triphosphatase - گوانوزین تری فسفاتاز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The mode of lymphocyte transendothelial migration in the postcapillary high endothelial venules (HEVs) of Peyer's patches during normal homing and acute inflammation in the guinea pig was studied. It is common opinion that the lymphocyte transendothelial passage from the blood stream into the extravasal lymphoid tissue calls for a multistep process of endothelial and lymphocyte molecules favoring tethering, rolling, activation, arrest and its firm adhesion to the endothelial luminal surface. Ultrastructural serial pictures and the three-dimensional reconstruction of HEVs with lymphocytes during different moments of their transmigration through the endothelial wall enabled us to demonstrate in vivo the morphological modality of their extravasation in lymphoid tissue. The latter is accomplished by means of an intraendothelial canalicular formation (6.8-7.2 μm long and 2.1-2.2 μm in diameter), whose creation depends on the particular behavior of adjacent endothelial cells, without compromising the interendothelial contacts. This new canalicular pathway of lymphocyte extravasation, particularly selective for the B cell, does not permit confirmation of the dogmas of the transcellular and paracellular (open interendothelial junctions) modes that have prevailed in recent decades. The lack of knowledge regarding the molecular bases that would induce constitution of this intraendothelial canalicular formation is a critical point for stimulating future interdisciplinary research aimed at developing strategies for modulating normal lymphocyte homing and in inflammation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microvascular Research - Volume 75, Issue 2, March 2008, Pages 227-237
Journal: Microvascular Research - Volume 75, Issue 2, March 2008, Pages 227-237
نویسندگان
Giacomo Azzali, Maria Luisa Arcari, Gaetano Felice Caldara,