کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1995944 1541475 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The paradoxical effects of vitamin D on type 1 mediated immunity
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
The paradoxical effects of vitamin D on type 1 mediated immunity
چکیده انگلیسی

Low vitamin D status is associated with an increased risk of Th1 mediated autoimmune diseases like inflammatory bowel disease. 1,25(OH)2D3 treatments have been shown to suppress Th1 mediated immunity and protect animals from experimental autoimmunity. Th1 mediated immunity is important for clearance of a number of different infectious diseases. For tuberculosis 1,25(OH)2D3 treatment is associated with decreased Th1 mediated immunity but increased bactericidal activity. Systemic candidiasis is unaffected by 1,25(OH)2D3 treatment. The seemingly paradoxical effects of 1,25(OH)2D3 and vitamin D on Th1 mediated autoimmunity versus infectious immunity point to a broad array of vitamin D targets in the immune system. The interplay of these vitamin D targets and their impact on the host-immune response then dictate the outcome.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Aspects of Medicine - Volume 29, Issue 6, December 2008, Pages 369–375
نویسندگان
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