Comparison of behavioral and biochemical deficits in rats with hereditary defined or d-galactose-induced accelerated senescence: Evaluating the protective effects of diosgenin

Chronic diosgenin treatment failed to improve biochemical and behavioral disturbances and had some undesirable side effects on body weight and working memory in OXYS rats. However, diosgenin restored moderately decreased sperm motility in d-galactose-treated Wistar males and might be recommended for treatment of mild age-related reproductive dysfunctions.