کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2014034 | 1067140 | 2009 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
d-cycloserine enhances short-delay, but not long-delay, conditioned taste aversion learning in rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
NMDA receptors have been implicated in conditioned taste aversion (CTA), a form of associative learning with the unique temporal characteristic of associating taste and toxic stimuli across very long delays. d-cycloserine (DCS), an NMDA receptor agonist, has been shown to enhance short-delay CTA learning. Here we examined the interaction of DCS with varying temporal parameters of CTA. DCS (15Â mg/kg) administered prior to the pairing of 0.125% saccharin and LiCl (38Â mM, 12Â ml/kg) enhanced CTA when there was a short delay between the taste-toxin pairing (10Â min), but not when there was a long delay (45Â min). DCS activity remained at effective levels over the long delay, because DCS administered 60Â min prior to a short-delay pairing enhanced CTA. The interaction of DCS with the delay between taste stimulus onset and LiCl injection was investigated by administering DCS and then 5Â min access to saccharin 45Â min prior to a short-delay pairing of saccharin and LiCl. DCS failed to enhance CTA in rats pre-exposed to saccharin, even with a short delay between the second saccharin exposure and LiCl injection. These results suggest that DCS enhancement of CTA is dependent on mechanisms underlying gustatory processing during long-delay taste-toxin associations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 91, Issue 4, February 2009, Pages 596-603
Journal: Pharmacology Biochemistry and Behavior - Volume 91, Issue 4, February 2009, Pages 596-603
نویسندگان
Rachel A. Davenport, Thomas A. Houpt,