Solubility of puerarin in the binary system of methanol and acetic acid solvent mixtures

The solubility of puerarin in methanol and acetic acid solvent mixtures was measured by a static analytical method at temperatures ranging from (293.15 to 333.15) K. The mass fraction of acetic acid in the solvent mixtures (w3) ranges from 0 to 0.6. The Apelblat equation was applied for correlating the experimental solubility data, and subsequently used to derive the apparent molar enthalpy, Gibbs energy, and entropy of dissolution of puerarin in methanol + acetic acid binary mixtures.

► New experimental data are provided for the solubility of puerarin.
► Nonlinear dependences were found for the variation of solubility with temperature.
► The nonlinear Apelblat equation was proposed for correlating the experimental data.
► The apparent molar enthalpies, Gibbs energy, and entropy of puerarin in the solvents were calculated.