کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2019209 1068563 2010 19 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease
چکیده انگلیسی

Simple bioactive sphingolipids include ceramide, sphingosine and their phosphorylated forms sphingosine 1-phosphate and ceramide 1-phosphate. These molecules are crucial regulators of cell functions. In particular, they play important roles in the regulation of angiogenesis, apoptosis, cell proliferation, differentiation, migration, and inflammation. Decoding the mechanisms by which these cellular functions are regulated requires detailed understanding of the signaling pathways that are implicated in these processes. Most importantly, the development of inhibitors of the enzymes involved in their metabolism may be crucial for establishing new therapeutic strategies for treatment of disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Lipid Research - Volume 49, Issue 4, October 2010, Pages 316–334
نویسندگان
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