کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2019519 1542219 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
15-Lipoxygenases in cancer: A double-edged sword?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
15-Lipoxygenases in cancer: A double-edged sword?
چکیده انگلیسی
Among the lipoxygenases, a diverse family of fatty acid dioxygenases with varying tissue-specific expression, 15-lipoxygenase (15-LOX) was found to be involved in many aspects of human cancer, such as angiogenesis, chronic inflammation, metastasis formation, and direct and indirect tumor suppression. Herein, evidence for the expression and action of 15-LOX and its orthologs in various neoplasms, including solid tumors and hematologic malignancies, is reviewed. The debate surrounding the impact of 15-LOX as either a tumor-promoting or a tumor-suppressing enzyme is highlighted and discussed in the context of its role in other biological systems.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Prostaglandins & Other Lipid Mediators - Volume 106, October 2013, Pages 16-22
نویسندگان
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