Hematopoietic prostaglandin D synthase (HPGDS): A high stability, Val187Ile isoenzyme common among African Americans and its relationship to risk for colorectal cancer

► We conducted a systematic survey of naturally occurring HPGDS enzyme variants. ► A high stability Val187Ile variant occurs in 8% of African Americans and 2% of Caucasians. ► Val187Ile does not protect against colon cancer. ► Other methods will be needed to establish a role for HPGDS in development of human intestinal tumors, as shown by mouse model data.