کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2019940 | 1542248 | 2007 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of direct albumin binding to sphingosylphosphorylcholine in Jurkat T cells
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
LPA, lysophosphatidic acid - LPA، اسید لیسوفسفیدیدLPC, lysophosphatidylcholine - LPC، lysophosphatidylcholineLPE, lysophosphatidylethanolamine - LPE، lysophosphatidylethanolamineS1P, sphingosine 1-phosphate - S1P، اسپینگوزین 1-فسفاتSPC, Sphingosylphosphorylcholine - SPC، SphingosylphosphorylcholineBSA, bovine serum albumin - آلبومین سرم گاویFBS, fetal bovine serum - سرم جنینی گاوی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
We investigated the effects of serum on lysophospholipid-induced cytotoxicity in Jurkat T cells. We found that sphingosylphosphorylcholine (SPC, also known as lysosphingomyelin) induced cytotoxicity and that albumin in serum could protect cells by binding directly to SPC. Furthermore, we also found that SPC induced ROS generation, increased [Ca2+]i, and decreased MMP. However, those effects were only observed at concentrations higher than 10 μM and were only induced in albumin-free media. Therefore, SPC may be trapped by albumin in plasma and unable to exert its effects under normal conditions, although at high concentrations, SPC could induce several responses such as ROS generation, increased [Ca2+]i, and decreased MMP in Jurkat T cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Prostaglandins & Other Lipid Mediators - Volume 84, Issues 3–4, November 2007, Pages 174–183
Journal: Prostaglandins & Other Lipid Mediators - Volume 84, Issues 3–4, November 2007, Pages 174–183
نویسندگان
Mijin Han, Yu-Lee Kim, Santosh J. Sacket, Kyeok Kim, Hyo-Lim Kim, Ji-Yeong Jo, Nam-Chul Ha, Dong-Soon Im,