کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2023769 1542544 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Embryonic stem cell miRNAs and their roles in development and disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Embryonic stem cell miRNAs and their roles in development and disease
چکیده انگلیسی

MicroRNAs have emerged as important modulators of gene expression. Both during development and disease, regulation by miRNAs controls the choice between self-renewal and differentiation, survival and apoptosis and dictates how cells respond to external stimuli. In mouse pluripotent embryonic stem cells, a surprisingly small set of miRNAs, encoded by four polycistronic genes is at the center of such decisions. miR-290–295, miR-302–367, miR-17–92 and miR-106b–25 encode for miRNAs with highly related sequences that seem to control largely overlapping gene sets. Recent studies have highlighted the importance of these miRNAs in the maintenance of ‘stemness’ and regulation of normal development and have linked the deregulation of their expression to a variety of human diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cancer Biology - Volume 22, Issues 5–6, October 2012, Pages 428–436
نویسندگان
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