کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2030566 1071218 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mitochondrial cytochrome c biogenesis: no longer an enigma
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Mitochondrial cytochrome c biogenesis: no longer an enigma
چکیده انگلیسی


• Mitochondrial HCCS attaches heme to cytochrome c by a four-step mechanism.
• Heme controls biogenesis by binding HCCS, thus allowing cytochrome to bind.
• Stereochemical attachment leads to the release of cytochrome c from HCCS.
• Mechanisms are compared to cytochrome biogenesis in bacteria with unifying themes.

Cytochromes c (cyt c) and c1 are heme proteins that are essential for aerobic respiration. Release of cyt c from mitochondria is an important signal in apoptosis initiation. Biogenesis of c-type cytochromes involves covalent attachment of heme to two cysteines (at a conserved CXXCH sequence) in the apocytochrome. Heme attachment is catalyzed in most mitochondria by holocytochrome c synthase (HCCS), which is also necessary for the import of apocytochrome c (apocyt c). Thus, HCCS affects cellular levels of cyt c, impacting mitochondrial physiology and cell death. Here, we review the mechanisms of HCCS function and the roles of heme and residues in the CXXCH motif. Additionally, we consider concepts emerging within the two prokaryotic cytochrome c biogenesis pathways.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 40, Issue 8, August 2015, Pages 446–455
نویسندگان
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