کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2030730 1071241 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Deciphering the retinoblastoma protein phosphorylation code
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Deciphering the retinoblastoma protein phosphorylation code
چکیده انگلیسی

Multisite phosphorylation modulates the function of regulatory proteins with complex signaling properties and outputs. The retinoblastoma tumor suppressor protein (Rb) is inactivated by cyclin-dependent kinase (Cdk) phosphorylation in normal and cancer cell cycles, so understanding the molecular mechanisms and effects of Rb phosphorylation is imperative. Rb functions in diverse processes regulating proliferation, and it has been speculated that multisite phosphorylation might act as a code in which discrete phosphorylations control specific activities. The idea of an Rb phosphorylation code is evaluated here in light of recent studies of Rb structure and function. Rb inactivation is discussed with an emphasis on how multisite phosphorylation changes Rb structure and associations with protein partners.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 38, Issue 1, January 2013, Pages 12–19
نویسندگان
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