کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
203125 | 460636 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Prediction of solubilities of pharmaceutical compounds in water + co-solvent systems using an activity coefficient model
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The prediction of the solubilities of pharmaceutical compounds in solvent and co-solvent systems can be achieved using a one-parameter Wilson activity coefficient model. The pharmaceutical compounds tested included salicylic acid, acetaminophen, benzocaine, acetanilide and phenacetin. The solvent employed was water, and the co-solvents studied were ethanol, methanol, and 1,4-dioxane. The solubilities of solutes in a binary mixture of water and co-solvent have been predicted on the basis of the solubility data of the solutes in pure solvent. The method was modified in order to obtain improved results using two ternary solubility data.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fluid Phase Equilibria - Volume 290, Issues 1–2, 25 March 2010, Pages 153–157
Journal: Fluid Phase Equilibria - Volume 290, Issues 1–2, 25 March 2010, Pages 153–157
نویسندگان
Hiroyuki Matsuda, Kenta Kaburagi, Kiyofumi Kurihara, Katsumi Tochigi, Kazuo Tomono,