کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2032518 1542878 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ameliorative effect of Morus alba leaves extract against developmental retinopathy in pups of diabetic and aluminum intoxicated pregnant albino rats
ترجمه فارسی عنوان
اثر تمیز کننده عصاره برگ موروس آلبا در برابر رتینوپاتی رشدی در موشهای آلبینو باردار دیابتی و آلوده به آلبومین آلوده به دیابت و آلومینیوم
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
چکیده انگلیسی

ABSTRACTObjectiveTo investigate the possible ameliorative effect of crude water extract of Morus alba (M. alba) leaves on retinopathy of rat pups maternally subjected to diabetes and/or Al intoxication.MethodsBoth control and experimental groups were subjected to certain integrated approaches, namely, biochemical assessments, light microscopic investigation, transmission electron microscopic investigation, single cell gel electrophoresis (comet assay) and determination of DNA fragmentation.ResultsThe retina of pups of diabetic and/or Al-intoxicated mothers exhibited abnormal alterations in retinal cell layers including retinal pigmented epithelium, photoreceptor inner segment and ganglion cells. Increased incidence of DNA fragmentation and apoptosis were evident in pups of diabetic and/or Al-intoxicated mothers. However, retina of pups maternally received M. alba extract plus diabetes or Al-intoxicated alone or in combination showed marked amelioration. Less degree of ameliorations was seen in retina of pups maternally subjected to combined treatment. Furthermore, application of crude water extract of M. alba resulted in amelioration of the alterations of maternal serum glucose as well as Al concentration.ConclusionsBased on the results of the present study, M. alba extract is effective against experimentally diabetic and Al-induced developmental retinopathy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Asian Pacific Journal of Tropical Biomedicine - Volume 5, Issue 4, April 2015, Pages 300–309
نویسندگان
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