کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2032539 1542865 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Phylogeny and drug resistance of HIV PR gene among HIV patients receiving RT inhibitors in Iran
ترجمه فارسی عنوان
بیماری فلوژی و مقاومت دارویی ژن PR-HIV در میان بیماران مبتلا به HIV دریافت کننده مهارکننده های RT در ایران
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
چکیده انگلیسی

ObjectiveTo survey the level and patterns of reverse transcriptase-based drug resistance and subtype distribution among antiretroviral-treated HIV-infected patients receiving only reverse transcriptase inhibitors in Iran.MethodsA total of 25 samples of antiretroviral therapy experienced patients with no history of using protease inhibitors were collected. After RNA extraction, reverse transcriptase-nested PCR was performed. The final products were sequenced and then analysed for drug-resistant mutations and subtypes.ResultsNo drug resistant mutations were observed among the 25 subjects. The results showed the following subtypes among patients: CRF 35_AD (88%), CRF 28_BF (8%), and CRF 29_BF (4%).ConclusionsA significant increase in drug resistance has been noted in recently-infected patients worldwide. Subtype distributions are needed to perform properly-designed surveillance studies to continuously monitor rates and patterns of transmitted drug resistance and subtypes to help guide therapeutic approaches and limit transmission of these variants.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Asian Pacific Journal of Tropical Biomedicine - Volume 6, Issue 5, May 2016, Pages 451–454
نویسندگان
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