کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2049100 1074116 2010 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An allostatic control of membrane lipid composition by SREBP1
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
An allostatic control of membrane lipid composition by SREBP1
چکیده انگلیسی

The maintenance of membrane lipid composition within strict limits is critical to maintain optimum cellular function. The biophysical properties of the membrane can be influenced among other factors by the saturation/unsaturation of the phospholipid fatty acyl chain. The rate-limiting enzyme in unsaturated fatty acid biosynthesis is the desaturase enzyme which in turn is regulated by the lipid transcription factor sterol regulatory element binding protein (SREBP1). In this review, we collect some evidence suggesting SREBP1 network as an important allostatic regulator necessary to maintain the pool of unsaturated fatty acid lipid species that can be incorporated into biological membranes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 12, 18 June 2010, Pages 2689–2698
نویسندگان
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