کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2070867 | 1544592 | 2014 | 16 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Cell therapy, 3D culture systems and tissue engineering for cardiac regeneration Cell therapy, 3D culture systems and tissue engineering for cardiac regeneration](/preview/png/2070867.png)
Ischemic Heart Disease (IHD) still represents the “Number One Killer” worldwide accounting for the death of numerous patients. However the capacity for self-regeneration of the adult heart is very limited and the loss of cardiomyocytes in the infarcted heart leads to continuous adverse cardiac-remodeling which often leads to heart-failure (HF). The concept of regenerative medicine comprising cell-based therapies, bio-engineering technologies and hybrid solutions has been proposed as a promising next-generation approach to address IHD and HF. Numerous strategies are under investigation evaluating the potential of regenerative medicine on the failing myocardium including classical cell-therapy concepts, three-dimensional culture techniques and tissue-engineering approaches. While most of these regenerative strategies have shown great potential in experimental studies, the translation into a clinical setting has either been limited or too rapid leaving many key questions unanswered. This review summarizes the current state-of-the-art, important challenges and future research directions as to regenerative approaches addressing IHD and resulting HF.
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Journal: Advanced Drug Delivery Reviews - Volumes 69–70, 20 April 2014, Pages 254–269