کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2070972 | 1078713 | 2013 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Carbon nanotubes as vectors for gene therapy: Past achievements, present challenges and future goals Carbon nanotubes as vectors for gene therapy: Past achievements, present challenges and future goals](/preview/png/2070972.png)
Promising therapeutic and prophylactic effects have been achieved following advances in the gene therapy research arena, giving birth to the new generation of disease-modifying therapeutics. The greatest challenge that gene therapy vectors still face is the ability to deliver sufficient genetic payloads in order to enable efficient gene transfer into target cells. A wide variety of viral and non-viral gene therapy vectors have been developed and explored over the past 10 years, including carbon nanotubes. In this review we will address the application of carbon nanotubes as non-viral vectors in gene therapy with the aim to give a perspective on the past achievements, present challenges and future goals. A series of important topics concerning carbon nanotubes as gene therapy vectors will be addressed, including the benefits that carbon nanotubes offer over other non-viral delivery systems. Furthermore, a perspective is given on what the ideal genetic cargo to deliver using carbon nanotubes is and finally the geno-pharmacological impact of carbon nanotube-mediated gene therapy is discussed.
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Journal: Advanced Drug Delivery Reviews - Volume 65, Issue 15, December 2013, Pages 2023–2033