کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2071280 1078737 2012 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
How to improve exposure of tumor cells to drugs — Promoter drugs increase tumor uptake and penetration of effector drugs
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
How to improve exposure of tumor cells to drugs — Promoter drugs increase tumor uptake and penetration of effector drugs
چکیده انگلیسی

Solid tumors are characterized by an abnormal architecture and composition that limit the uptake and distribution of antitumor drugs. Over the last two decades, drugs have been identified that improve the tumor uptake and distribution of drugs that have direct antitumor effects. We propose to refer to these drugs as promoter drugs, and as effector drugs to drugs that have direct antitumor effects. Some promoter drugs have received regulatory approval, while others are in active clinical development. This review gives an overview of promoter drugs, by classifying them according to their mechanism of action: promoter drugs that modulate tumor blood flow, modify the barrier function of tumor vessels, induce tumor cell killing, and overcome stromal barriers. Eventually, we discuss those that we feel are the main conclusions to be drawn from promoter drug research that has been performed so far, and suggest areas of future investigation to improve the efficacy of promoter drugs in cancer therapy.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advanced Drug Delivery Reviews - Volume 64, Issue 1, January 2012, Pages 53–68
نویسندگان
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