کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2071289 1078738 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tumor delivery of macromolecular drugs based on the EPR effect
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Tumor delivery of macromolecular drugs based on the EPR effect
چکیده انگلیسی

Enhanced permeability and retention (EPR) effect is the physiology-based principal mechanism of tumor accumulation of large molecules and small particles. This specific issue of Advanced Drug Delivery Reviews is summing up multiple data on the EPR effect-based drug design and clinical outcome. In this commentary, the role of the EPR effect in the intratumoral delivery of protein and peptide drugs, macromolecular drugs and drug-loaded long-circulating pharmaceutical nanocarriers is briefly discussed together with some additional opportunities for drug delivery arising from the initial EPR effect-mediated accumulation of drug-containing macromolecular systems in tumors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advanced Drug Delivery Reviews - Volume 63, Issue 3, 18 March 2011, Pages 131–135
نویسندگان
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