کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2076343 1079439 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanisms of developmental robustness
موضوعات مرتبط
مهندسی و علوم پایه ریاضیات مدل‌سازی و شبیه سازی
پیش نمایش صفحه اول مقاله
Mechanisms of developmental robustness
چکیده انگلیسی

We present a review of noise buffering mechanisms responsible for developmental robustness. We focus on functions of chaperone Hsp90, miRNA, and cross-regulation of gap genes in Drosophila. The noise buffering mechanisms associated with these functions represent specific examples of the developmental canalization, reducing the phenotypical variability in presence of either genetic or environmental perturbations. We demonstrate that robustness often appears as a function of a network of interacting elements and that the system level approach is needed to understand the mechanisms of noise filtering.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosystems - Volume 109, Issue 3, September 2012, Pages 329–335
نویسندگان
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