کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2081236 1545211 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structure-based development of target-specific compound libraries
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Structure-based development of target-specific compound libraries
چکیده انگلیسی

The success or failure of a small-molecule drug discovery project ultimately lies in the choice of the scaffolds to be screened – chosen from among the many millions of available compounds. Therefore, the methods used to design compound screening libraries are key for the development of new drugs that target a wide range of diseases. Currently, there is a trend towards the construction of receptor-structure-based focused libraries. Recent advances in high-throughput computational docking, NMR and crystallography have facilitated the development of these libraries. A structure-based target-specific library can save time and money by reducing the number of compounds to be experimentally tested, also improving the drug discovery success rate by identifying more-potent and specific binders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Discovery Today - Volume 11, Issues 5–6, March 2006, Pages 261–266
نویسندگان
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