کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2084340 1545388 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preparation and characterization of mucinated cellulose microparticles for therapeutic and drug delivery purposes
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Preparation and characterization of mucinated cellulose microparticles for therapeutic and drug delivery purposes
چکیده انگلیسی
Mucinated cellulose microparticles were generated by mixing equal concentrations of colloidal dispersions of porcine mucin (Mc) and microcrystalline cellulose (MCC). The hybrid polymer was recovered by precipitating at controlled temperature and pH conditions using acetone. Some physicochemical, functional and thermal properties of the hybrid polymer were determined and compared with those of Mc and MCC. The new polymer Mc-MCC had swelling and moisture sorption profiles that were different from those of Mc and MCC in buffer solutions with different pH values and relative humidity, respectively. The mucoadhesive property of the new polymer was similar to that of Mc. The scanning electron micrographs (SEMs) showed that the microparticles generated from the hybridization were similar to those of MCC, but with larger and denser particles. The Fourier Transform Infrared (FT-IR) spectrum and Differential Scanning Calorimeter (DSC) thermogram of the hybrid polymer were characteristically different from those of Mc and MCC. The presence of new peaks in the FT-IR spectrum and distinct cold crystallization exotherm, which were absent in both Mc and MCC, confirms the formation of a new polymer type with synergistic physicochemical and functional properties.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 72, Issue 1, May 2009, Pages 34-41
نویسندگان
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