Radiosensitizing potential of Plumbagin in B16F1 melanoma tumor cells through mitochondrial mediated programmed cell death

- PLB treatment prior to radiation exposure reduced clonogenicity of B16F1 cells.
- PLB augmented radiation induced DNA damage, ROS and depletion of Ψm.
- PLB elevated radiation induced p53, Bax, Cytochrome c, cleaved PARP and Caspase 3.