کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
210432 | 461710 | 2012 | 8 صفحه PDF | دانلود رایگان |
A series of solid base catalysts were synthesized by functionalization of different weight fractions (5, 10, and 15 wt.%) of 3-aminopropyltrimethoxysilane (APTMS) on thermally activated F- type fly ash (SiO2 and Al2O3 > 70%). Catalyst characterization was undertaken using different analytical techniques such as FTIR, XRD, SEM–EDX, TEM, N2− adsorption desorption, BET surface area analysis, TGA and AAS. The results showed that appropriate amount (10 wt.%) of aminopropyl groups results in excellent catalytic performance tested for condensation of ethyl cyanoacetate and cyclohexanone at 120 °C to produce Ethyl (cyclohexylidene) cyanoacetate (92% yield), an important intermediate of gabapentin (Neurontin), widely used in the treatment of epilepsy to relieve neuropathic pain, under solvent free conditions and in low cost route. The catalyst NH2FA-10 was reusable up to three reaction cycles. The work reports an innovative use of solid waste fly ash as an effective solid base catalyst.
► A solid base catalyst (NH2FA-10) was synthesized from F-type fly ash.
► 3-Aminopropyltrimethoxysilane was functionalized over thermally activated fly ash.
► The catalyst was used for production of gabapentin through condensation.
► The catalyst was reusable up to 3 reaction cycles.
Journal: Fuel Processing Technology - Volume 95, March 2012, Pages 119–126