کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2130014 | 1086517 | 2016 | 8 صفحه PDF | دانلود رایگان |
• The lateral element of the synaptonemal complex is a multilayered structure.
• The width of the lateral element in synaptonemal complex-null mice is different.
• Two cohesin complex cores plus one axial element form a wild-type lateral element.
• The layers of the lateral element can be analyzed in different null mice models.
The synaptonemal complex (SC) is a proteinaceous structure that holds the homologous chromosomes in close proximity while they exchange genetic material in a process known as meiotic recombination. This meiotic recombination leads to genetic variability in sexually reproducing organisms. The ultrastructure of the SC is studied by electron microscopy and it is observed as a tripartite structure. Two lateral elements (LE) separated by a central region (CR) confer its classical tripartite organization. The LEs are the anchoring platform for the replicated homologous chromosomes to properly exchange genetic material with one another. An accurate assembly of the LE is indispensable for the proper completion of meiosis. Ultrastructural studies suggested that the LE is organized as a multilayered unit. However, no validation of this model has been previously provided. In this ultrastructural study, by using mice with different genetic backgrounds that affect the LE width, we provide further evidence that support a multilayered organization of the LE. Additionally, we provide data suggesting additional roles of the different cohesin complex components in the structure of the LEs of the SC.
Figure optionsDownload high-quality image (286 K)Download as PowerPoint slide
Journal: Experimental Cell Research - Volume 344, Issue 1, 15 May 2016, Pages 22–29