کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2130284 | 1086549 | 2014 | 19 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Rab proteins: The key regulators of intracellular vesicle transport Rab proteins: The key regulators of intracellular vesicle transport](/preview/png/2130284.png)
• Rab proteins regulate different signalling pathways.
• Deregulation of Rabs is the fundamental causes of a variety of human diseases.
• This paper gives potential directions in developing therapeutic targets.
• This paper also gives ample directions for modulating pathways central to normal physiology.
• These are the huge challenges for drug discovery and delivery in near future.
Vesicular/membrane trafficking essentially regulates the compartmentalization and abundance of proteins within the cells and contributes in many signalling pathways. This membrane transport in eukaryotic cells is a complex process regulated by a large and diverse array of proteins. A large group of monomeric small GTPases; the Rabs are essential components of this membrane trafficking route. Most of the Rabs are ubiquitously expressed proteins and have been implicated in vesicle formation, vesicle motility/delivery along cytoskeleton elements and docking/fusion at target membranes through the recruitment of effectors. Functional impairments of Rabs affecting transport pathways manifest different diseases. Rab functions are accompanied by cyclical activation and inactivation of GTP-bound and GDP-bound forms between the cytosol and membranes which is regulated by upstream regulators. Rab proteins are characterized by their distinct sub-cellular localization and regulate a wide variety of endocytic, transcytic and exocytic transport pathways. Mutations of Rabs affect cell growth, motility and other biological processes.
Journal: Experimental Cell Research - Volume 328, Issue 1, 15 October 2014, Pages 1–19