کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2130383 | 1547706 | 2014 | 9 صفحه PDF | دانلود رایگان |
●miR-26a directly target ATM in GBM cells.●miR-26a enhances the radiosensitivity of GBM cells.●miR-26a could reduce the DNA repair capacity of GBM cells.
Glioblastoma multiforme (GBM) is notoriously resistant to radiation, and consequently, new radiosensitizers are urgently needed. MicroRNAs are a class of endogenous gene modulators with emerging roles in DNA repair. We found that overexpression of miR-26a can enhance radiosensitivity and reduce the DNA repair ability of U87 cells. However, knockdown miR-26a in U87 cells could act the converse manner. Mechanistically, this effect is mediated by direct targeting of miR-26a to the 3′UTR of ATM, which leads to reduced ATM levels and consequent inhibition of the homologous recombination repair pathway. These results suggest that miR-26a may act as a new radiosensitizer of GBM.
Journal: Experimental Cell Research - Volume 320, Issue 2, 15 January 2014, Pages 200–208