کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2130759 1086598 2011 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Wnt signaling and colon tumorigenesis — A view from the periphery
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Wnt signaling and colon tumorigenesis — A view from the periphery
چکیده انگلیسی

In this brief overview we discuss the association between Wnt signaling and colon cell biology and tumorigenesis. Our current understanding of the role of Apc in the β-catenin destruction complex is compared with potential roles for Apc in cell adhesion and migration. The requirement for phosphorylation in the proteasomal-mediated degradation of β-catenin is contrasted with roles for phospho-β-catenin in the activation of transcription, cell adhesion and migration. The synergy between Myb and β-catenin regulation of transcription in crypt stem cells during Wnt signaling is discussed. Finally, potential effects of growth factor regulatory systems, Apc or truncated-Apc on crypt morphogenesis, stem cell localization and crypt fission are considered.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 317, Issue 19, 15 November 2011, Pages 2748–2758
نویسندگان
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