کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2131312 1086633 2010 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification of a lysine-rich region of Fas as a raft nanodomain targeting signal necessary for Fas-mediated cell death
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Identification of a lysine-rich region of Fas as a raft nanodomain targeting signal necessary for Fas-mediated cell death
چکیده انگلیسی

Fas interaction at the plasma membrane with its lipid and protein environment plays a crucial role in the early steps of Fas signalling induced by Fas ligand binding. Particularly, Fas localisation in the raft nanodomains, ezrin-mediated interaction with the actin cytoskeleton and subsequent internalization are critical steps in Fas-mediated cell death. We identified a lysine-rich region (LRR) in the cytoplasmic, membrane-proximal region of Fas as a key determinant modulating these initial events. Through a genetic approach, we demonstrate that Fas LRR represents another signal additional to palmitoylation targeting Fas to the raft nanodomains, and modulates Fas interaction with the cytoskeleton.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 316, Issue 9, 15 May 2010, Pages 1513–1522
نویسندگان
, , , , , , ,