کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2131679 1086654 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intracellular trafficking of Notch receptors and ligands
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Intracellular trafficking of Notch receptors and ligands
چکیده انگلیسی

The Notch pathway represents a highly conserved signaling network, which regulates the formation and maintenance of various organ systems along development and during adulthood. Direct cell–cell contacts between ligand- and receptor-expressing cells underlie activation of the Notch pathway. Notch signaling requires endocytosis in both signal emitting and receiving cells. Recent findings on the roles of a number of modulators show that they act either on the maintenance of an active receptor at the membrane, or on the production of active ligand, or on signal transduction after activation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 315, Issue 9, 15 May 2009, Pages 1549–1555
نویسندگان
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