کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2132122 1086675 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cellular senescence and DNA repair
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Cellular senescence and DNA repair
چکیده انگلیسی

Aging is a complex process that results in functional decline and mortality of the organisms. On the cellular lever, cellular senescence has been used as a model for aging. Therefore, understanding cellular senescence has important health implications. Initial observations suggest that cellular senescence is the result of telomere shortening. Recent findings suggest that cellular senescence could be triggered by DNA damage. In fact, both telomere shortening and DNA-damage-induced cellular senescence share a common mechanism, the DNA damage response pathway. This review will discuss the link between DNA repair defects and cellular senescence.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 312, Issue 14, 15 August 2006, Pages 2641–2646
نویسندگان
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