کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2132797 1086719 2008 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
TGF-β induces formation of F-actin cores and matrix degradation in human breast cancer cells via distinct signaling pathways
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
TGF-β induces formation of F-actin cores and matrix degradation in human breast cancer cells via distinct signaling pathways
چکیده انگلیسی

Transforming growth factor beta regulates many biological processes including cell motility and invasion. Podosomes are specialized F-actin rich structures found in normal cells, such as osteoclasts and macrophages. Tumor cells often form related structures called invadopodia that are thought to promote invasion and metastasis. Here we show that human breast cancer cells organize F-actin rich structures in response to transforming growth factor beta that colocalize with areas of extracellular matrix degradation. We further show that organizing the complex of proteins needed to form these structures requires signaling through phosphatidylinositide 3-kinase and Src kinase, while activating the proteases involved in degradation of extracellular matrix requires extracellular signal-regulated kinase signaling, and that each of these pathways is activated by transforming growth factor beta in CA1D human breast cancer cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 314, Issue 19, 15 November 2008, Pages 3478–3493
نویسندگان
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