Determination and correlation of cefuroxime acid solubility in (acetonitrile + water) mixtures

• The solubility of cefuroxime acid in different solvents was experimentally determined.
• The experimental solubility data were correlated by three models.
• The AIC was used to select the best solubility model.
• The thermodynamic properties of cefuroxime acid in solution were obtained.

The solubility of cefuroxime acid in (acetonitrile + water) mixtures was experimentally determined at temperatures from (278.15 to 313.15) K by using a dynamic method at atmospheric pressure. The solubility increased with the increasing of temperature, and it reached the maximum at acetonitrile molar fraction of 0.713 at constant temperature. The experimental solubility data were correlated well by using the modified Apelblat equation, the λh equation and the van’t Hoff equation, respectively. The Akaike’s Information Criterion (AIC) was used to select the best model for correlating the solubility of cefuroxime acid. Furthermore, the dissolution enthalpy, entropy and Gibbs free energy change of cefuroxime acid were also calculated by using the van’t Hoff equation.