کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2184161 1550304 2006 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Receptors and ligands involved in viral induction of type I interferon production by plasmacytoid dendritic cells
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Receptors and ligands involved in viral induction of type I interferon production by plasmacytoid dendritic cells
چکیده انگلیسی
Virus infection is sensed by the innate immune system which then rapidly initiates biosynthesis of type I interferon (IFN). The IFN signaling systems produce a broadly effective innate antiviral response by creating an antiviral state in both an autocrine and paracrine manner in cells and by activating innate and adaptive immunity. Plasmacytoid dendritic cells (pDCs) have the unique ability to produce very high levels of type I IFN following viral infection in vivo. Most recent research has focused on oligonucleotide-mediated induction of type I IFN production, implicating viral genome and replication intermediates as the stimulus for this response. However there are additional viral ligands which can potentially induce type I IFN production in pDCs, such as envelope glycoproteins, viral glycolipids, tegument, capsid or nuclear proteins. This area of viral immunology, which has been neglected in the literature, will be discussed here.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunobiology - Volume 211, Issues 6–8, 14 September 2006, Pages 525-535
نویسندگان
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