کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
219046 463242 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Electrocatalytic oxidation and the simultaneous determination of guanine and adenine on (2,6-pyridinedicarboxylic acid)/graphene composite film modified electrode
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Electrocatalytic oxidation and the simultaneous determination of guanine and adenine on (2,6-pyridinedicarboxylic acid)/graphene composite film modified electrode
چکیده انگلیسی


• The poly (2,6-pyridinedicarboxylic acid)/CRGO nanocomposite was prepared.
• The composite exhibited efficient electron transfer promotion.
• The nanocomposite displayed accumulation enhancement towards DNA bases.
• PPDA/CRGO/GCE exhibits excellent performances for the determination of DNA bases.

An electrochemical sensor was fabricated and used to simultaneously determine guanine and adenine in DNA. In this work, the poly (2,6-pyridinedicarboxylic acid)/chemically reduced graphene oxide modified glass electrode (PPDA/CRGO/GCE) was constructed. The PPDA/CRGO/GCE was characterized by scanning electron microscopy. The modified electrode displayed greatly improved voltammetric response to guanine (G) and adenine (A). Differential pulse voltammetry (DPV) was used for individual or simultaneous determination of guanine and adenine. The electrode showed good reproducibility with linear ranges of 0.05–4.5 μM and 0.1–6.0 μM, detection limits of 0.01 μM and 0.02 μM for guanine and adenine, respectively. The electrochemical method for the measurement of guanine and adenine in calf thymus DNA was also developed and the result was satisfactory.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Electroanalytical Chemistry - Volume 704, 1 September 2013, Pages 44–49
نویسندگان
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