کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2202027 | 1551322 | 2007 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The mitochondrial permeability transition in neurologic disease
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کلمات کلیدی
Ammonia - آمونیاکhepatic encephalopathy - آنسفالوپاتی کبدیamyotrophic lateral sclerosis - اسکلروز جانبی آمیوتروفیکmitochondrial permeability transition - انتقال نفوذپذیری میتوکندریexcitotoxicity - اکسید سمیتIschemia - ایسکمیAlzheimer's disease - بیماری آلزایمرHuntington's disease - بیماری هانتینگتونParkinson's disease - بیماری پارکینسونTrauma - تروماOxidative stress - تنش اکسیداتیوApoptosis - خزان یاختهایReye's syndrome - سندروم ریcyclosporin A - سیکلوسپورین ACell death - مرگ سلولی Manganese - منگنز Mitochondria - میتوکندریاCalcium homeostasis - هوموستاز کلسیم
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Mitochondria, being the principal source of cellular energy, are vital for cell life. Yet, ironically, they are also major mediators of cell death, either by necrosis or apoptosis. One means by which these adverse effects occur is through the mitochondrial permeability transition (mPT) whereby the inner mitochondrial membrane suddenly becomes excessively permeable to ions and other solutes, resulting in a collapse of the inner membrane potential, ultimately leading to energy failure and cell necrosis. The mPT may also bring about the release of various factors known to cause apoptotic cell death. The principal factors leading to the mPT are elevated levels of intracellular Ca2+ and oxidative stress. Characteristically, the mPT is inhibited by cyclosporin A. This article will briefly discuss the concept of the mPT, its molecular composition, its inducers and regulators, agents that influence its activity and describe the consequences of its induction. Lastly, we will review its potential contribution to acute neurological disorders, including ischemia, trauma, and toxic-metabolic conditions, as well as its role in chronic neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurochemistry International - Volume 50, Issues 7â8, June 2007, Pages 983-997
Journal: Neurochemistry International - Volume 50, Issues 7â8, June 2007, Pages 983-997
نویسندگان
M.D. Norenberg, K.V. Rama Rao,