کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
221410 463396 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Electrooxidation mechanism of non-steroidal anti-inflammatory drug piroxicam at glassy carbon electrode
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Electrooxidation mechanism of non-steroidal anti-inflammatory drug piroxicam at glassy carbon electrode
چکیده انگلیسی

The electrochemical oxidation behavior of the anti-inflammatory drug piroxicam at the glassy carbon electrode in 10% ACN + 90% 0.2 M Britton–Robinson Buffer is presented. Cyclic voltammetry, controlled potential electrolysis and spectroscopic techniques were used to obtain information about the reaction mechanism and product identification. After exhaustive electrolysis, the extraction followed by chromatographic separation of the reaction products gave the oxidized compounds. Using UV–Vis, GC–MS, 1H and 13C NMR techniques as well as the results of our preceding electrochemical investigation, 2-{[(carboxycarbonyl)(methyl)amino]sulfonyl}benzoic acid and 2-aminopyridine were identified. To account for the formation of these products, a detailed interpretation of the mechanism of the electrooxidation of piroxicam in acidic-buffered media was presented.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Electroanalytical Chemistry - Volume 588, Issue 2, 15 March 2006, Pages 218–225
نویسندگان
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