Degradation of Rabeprazole-N-oxide in aqueous solution using sonication as an advanced oxidation process

The degradation of Rabeprazole-N-oxide with sonication (US), peroxide mediated sonication (US/H2O2), Sono-Fenton (US/Fenton), TiO2 mediated sonication (US/TiO2) and sonication in combination with H2O2 and TiO2 (US/TiO2 + H2O2) is investigated and compared for their treatment efficiency. The effects of the frequency, power, different reactant concentrations and pH on the degradation rate have been examined. The efficiency of the treatment system is measured in terms of compound degradation and COD reduction. Among all the treatment processes studied, US/TiO2 + H2O2 is observed to be effective in degrading the drug impurity. A maximum of 72% degradation of the compound is observed at pH 7 with 50 mg of TiO2 and peroxide concentration of 500 mg/L.