Toward biotechnological production of adipic acid and precursors from biorenewables

Adipic acid is the most important commercial aliphatic dicarboxylic acid in the chemical industry and is primarily used for the production of nylon-6,6 polyamide. The current adipic acid market volume is about 2.6 million tons/y and the average annual demand growth rate forecast to stay at 3–3.5% worldwide. Hitherto, the industrial production of adipic acid is carried out by petroleum-based chemo-catalytic processes from non-renewable fossil fuels. However, in the past years, efforts were made to find alternative routes for adipic acid production from renewable carbon sources by biotechnological processes. Here we review the approaches and the progress made toward bio-based production of adipic acid.

► We summarized the basic mode of access to bio-based adipic acid.
► We reviewed the attempts for production of the adipic acid precursor cis, cis-muconic acid.
► We reviewed new recent options toward production of bio-based adipic acid.